Dr. van Haeringen Laboratorium B.V.

K386 Mucopolysaccharidosis I

Background

Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disease characterized by intracellular accumulation of the glycosaminoglycans (GAGs) dermatan and heparan sulfates. Affected cats have flat, broad faces, large heads, small ears, thick skin over the dorsal neck, wide cervical vertebrae, and hip subluxation. Other signs include abnormal gait, corneal clouding and some have a cardiac murmur of mitral insufficiency.

Test specific information

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Age

Symptoms will develop at a young age. Within a few hours to a maximum of several weeks after birth, the characteristics that go with these genetic effects will become visible.

Turn Around Time

The turn-around-time of a test depends to a large extent on the logistics of sample transportation to the laboratory. After receiving the sample at the test location, you can normally expect the result within 10 working days. A longer delivery time applies to tests carried out by a Partner Lab.

Location of disease or trait

Metabolic diseases comprise a group of diseases in which the metabolism of nutrients in the body cells of a patient is affected. Typically, the metabolism is not working correctly due to missing (deficiency) of an enzyme or protein. The function of the enzyme in the metabolic process influences the gravity of the symptoms.

Breed dependence

This DNA test is available for the following breeds: Domestic Short Hair. Additional information is available in the Frequently Asked Questions (FAQ).

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Swab, Tissue. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.

An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding 50 percent of the offspring will receive the disease allele. Carriers will not become ill.

An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected will become ill.

Inheritance

This genetic factor is inherited in an autosomal, recessive, mode. This means, that the individual can be free of the disease (homozygote normal), affected (homozygous affected) or carrier (heterozygous).

Carriers may spread the mutation in a population without showing symptoms themselves. Because of this, it is extremely important to identify carriers correctly to prevent spreading of a mutation.

Severity of Disease

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Code K386

Mucopolysaccharidosis I

€ 47,80 (Incl. 21% VAT)
€ 39,50 (Excl. VAT)
Quantity