During the last decades, a large number of scientific publications have described the genetic principles of coat colour and coat variation. Coat colours and coat variations are influenced by many hereditary factors. The DNA-tests are based on physiological effects in the body, in which the production and distribution of pigments result in many coat colour variants. In several cases, the coat colour of an animal may only be decided using DNA-tests.
The lysophosphatidic acid receptor 6 (LPAR6) gene influences the hair formation. The Cornish Rex, Curly/woolly coat test (K502) tests for the genetic status of the LPAR6 gene. The LPAR6 gene has two variants (alleles). The allele N is dominant and does not have an effect on the coat. Only when the cat has two copies of the recessive allele CC the coat is curly/woolly. The mutation is fixed in Cornish Rex cats. The test can be used in outcrossing programs, to help breeders select the cats that can produce curly coat in the next generation.
Test specific information
Since 2015, two brands have been developed. CombiGen®
is mainly directed at veterinarian applications, whereas CombiBreed®
is mainly directed at breeders and/or owners.
Detailed information about Coat Colours and Coat Variation is presented at www.combibreed.com.
The genetic factor is continuously present, and will always be visible.
Turn Around Time
The turn-around-time of a test depends to a large extent on the logistics of sample transportation to the laboratory. After receiving the sample at the test location, you can normally expect the result within 10 working days. A longer delivery time applies to tests carried out by a Partner Lab.
Location of disease or trait
Genetic factors influencing coat colours and coat types are usually visible on the outside of an individual. Several factors may be hidden by the external variation.
This DNA test is available for the following breeds: Cornish Rex, German Rex. Additional information is available in the Frequently Asked Questions (FAQ).
For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Swab, Tissue. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.
Coat colours are based on many genetic factors. For each factor, a separate test result will be returned.
Various genetic factors influencing coat colour and coat types are inherited in a dominant or recessive mode. Coat colours are influenced by a large number of genetic factors.
Severity of Disease