K865 CombiBreed Genetic Diseases

Background

This Combination Pack contains several important traits and can be based on samples from animals at any age. Information on individual tests is available at our website.

Two tests for Glycogentoxicosis GSD Type IV (K751) and Spinal Muscular Atrophie (SMA) (K767) needed to be removed from the combination package for technical reasons. We have the option, only in our webshop, to offer you these tests in combination with the remaining Combibreed package at a reduced price of € 7,50 (per test) when ordered at the same time in our webshop. This option is only available for the tests K751 and K767 in combination with: CombiBreed Genetic Diseases (K865), CombiBreed Hair Length (K460) or CombiBreed Coat Colour (K866).

This combination package includes DNA-tests for:
• K386 Mucopolysaccharidosis I
• K504 Periodic paralysis (WNK4 - Hypokalemia)
• K597 Congenital Adrenal Hyperplasia
• K598 Dihydropyrimidinase Deficiency
• K599 Hyperlipoproteinaemia
• K600 Niemann-Pick C1 Disease
• K601 Primary Hyperoxaluria II
• K640 Gangliosidosis, GM2, type II - 1
• K641 Vitamin D-deficiency rickets, type I
• K646 Gangliosidosis, GM2, GM2A
• K647 Gangliosidosis, GM2, type II - 2
• K649 Hypothyroidism
• K650 Mucopolysaccharidosis VII
• K651 Mucopolysaccharidosis VI
• K656 Haemophilia B - 1
• K657 Haemophilia B - 2
• K711 Polycystic Kidney Disease (PKD)
• K725 Hypertrophic Cardio Myopathy 1 (HCM1)
• K754 Pyruvaatkinase Deficiency (PKDef)
• K762 Progressive Retinal Atrophy (rdAc-PRA)
• K793 Bloodtyping AB (DNA test)
• K799 Hypertrophic Cardio Myopathy 3 (HCM3)

Test specific information

Dr. van Haeringen Laboratorium B.V. (VHL), introduces a different strategy for DNA tests for several genetic markers. Recently, technical improvements have allowed for the combination of several genetic markers in one test.

Several tests are available in different breeds. For the different mutations, clinical studies linking a mutation to HCM are not always available. It is up to the owner to decide which test to perform.

Based on a recent inventory at other laboratories, we have learned that the test for HCM2 is not offered internationally. Consequently, we have contacted researchers in the USA. Based on our current information, we have decided to remove the HCM2 test as of the end of February 2012 from the Combination Package for Hereditary Diseases. For the moment, the HCM2 test remains available as a separate test.