Dr. van Haeringen Laboratorium B.V.

H340 Canine Brachycephaly

Background

Facial retrusion is common to brachycephalic dog breeds. A genetic study identified a quantitative trait loci (QTL) on CFA1, which considerably contributes to face length variation. Most likely causative is an intronic LINE-1 sequence within the SMOC2 gene, which reduces SMOC2 expression in brachycephalic dogs. The LINE-1 sequence was found in 91,5% of chromosomes of brachycephalic dogs but only 2,1% of chromosomes of non-brachycephalic dogs.

Test specific information

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Age

Symptoms will develop at a young age. Within a few hours to a maximum of several weeks after birth, the characteristics that go with these genetic effects will become visible.

Turnaround time

The Turnaround Time (TAT) depends on various factors, such as the shipment time of your sample to the test location, the test method(s) and whether the tests are performed completely or partially by a Partner Lab or Patent owner.

The TAT of tests performed at our facilities is normally 10 working days after receipt of the sample at the testing laboratory (VHL, VHP or Certagen). For tests performed by a Partner Laboratory (so-called "partner lab test") or patent owner, the TAT is at least 20 working days after receipt of your sample. Because the shipment time to our Partner Labs or patent owner may vary due to factors we cannot influence, the mentioned 20 working days are therefore an estimate.

PLEASE NOTE
Sometimes it is necessary to re-run your sample. We call this a retest. In that case, the TAT will of course be extended.

Location of disease or trait

This disease is present in the entire body, but causes main effects in the internal organs such as stomach, intestinal tract, liver and / or kidneys. In a number of cases, the disease affects one major internal organ.

Breed dependence

This DNA test is available for the following breeds: Affenpinscher, Boston Terrier, Boxer, Bull Mastif, Cane Corso, Cavalier King Charles Spaniel, Chihuahua, Dogue de Bordeaux, English Bulldog, French Bulldog, Griffon Bruxellois, Japanese Chin, Mastiffs, Neapolitan Mastiff, Pekingese, Pug Dog, Rottweiler, Shih Tzu. Additional information is available in the Frequently Asked Questions (FAQ).

Sample type

For this DNA test we accept the following materials: Semen, Swab, Blood EDTA, Blood Heparin, Hair. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

Inheritance

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Severity of Disease

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Code H340

Canine Brachycephaly

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