Heritable polyneuropathies are a heterogenous group of diseases which affect the peripheral nervous system. In the Leonberger breed, the age-of-onset of clinical signs can vary from less than 1 year up to 11 years of age. Dogs with juvenile-onset disorder (LPN1) typically have a more severe and rapidly progressing course of disease. This suggests the existence of at least two distinct polyneuropathies in the breed. A likely causative mutation for a second inherited form of the disease with a wider range of onset, termed LPN2, was found in the GJA9 gene. This gene encodes a protein which is an important component of peripheral myelinated nerve fibers. The inheritance of LPN2 is incompletely dominant.
Test specific information
The disease may show itself on different ages, in which it cannot be estimated when the first symptoms may show themselves. Differences may exist between littermates, and between breeds.
Turn Around Time
The turn-around-time of a test depends to a large extent on the logistics of sample transportation to the laboratory. After receiving the sample at the test location, you can normally expect the result within 10 working days. A longer delivery time applies to tests carried out by a Partner Lab.
Location of disease or trait
This disease is present in the entire body, but causes main effects in the internal organs such as stomach, intestinal tract, liver and / or kidneys. In a number of cases, the disease affects one major internal organ.
This DNA test is available for the following breeds: Leonberger. Additional information is available in the Frequently Asked Questions (FAQ).
For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Tissue, Semen, Swab. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.
This genetic factor is inherited in an autosomal, dominant, mode. This means, that the individual can be free of the mutation (homozygote normal), affected (homozygous affected) or carrier (heterozygous affected). Both carriers and affected individuals will show symptoms of the mutation.
Severity of Disease