Heritable polyneuropathies are a heterogenous group of diseases which affect the peripheral nervous system. In the Leonberger breed, the age-of-onset of clinical signs can vary from less than 1 year up to 11 years of age. Dogs with juvenile-onset disorder (LPN1) typically have a more severe and rapidly progressing course of disease. This suggests the existence of at least two distinct polyneuropathies in the breed. A likely causative mutation for a second inherited form of the disease with a wider range of onset, termed LPN2, was found in the GJA9 gene. This gene encodes a protein which is an important component of peripheral myelinated nerve fibers. The inheritance of LPN2 is incompletely dominant.
Test specific information
The disease may show itself on different ages, in which it cannot be estimated when the first symptoms may show themselves. Differences may exist between littermates, and between breeds.
The Turnaround Time (TAT) depends on various factors, such as the shipment time of your sample to the test location, the test method(s) and whether the tests are performed completely or partially by a Partner Lab or Patent owner.
The TAT of tests performed at our facilities is normally 10 working days after receipt of the sample at the testing laboratory (VHL, VHP or Certagen). For tests performed by a Partner Laboratory (so-called "partner lab test") or patent owner, the TAT is at least 20 working days after receipt of your sample. Because the shipment time to our Partner Labs or patent owner may vary due to factors we cannot influence, the mentioned 20 working days are therefore an estimate.
Sometimes it is necessary to re-run your sample. We call this a retest. In that case, the TAT will of course be extended.
Location of disease or trait
This disease is present in the entire body, but causes main effects in the internal organs such as stomach, intestinal tract, liver and / or kidneys. In a number of cases, the disease affects one major internal organ.
This DNA test is available for the following breeds: Leonberger. Additional information is available in the Frequently Asked Questions (FAQ).
For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Tissue, Semen, Swab. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.
This genetic factor is inherited in an autosomal, dominant, mode. This means, that the individual can be free of the mutation (homozygote normal), affected (homozygous affected) or carrier (heterozygous affected). Both carriers and affected individuals will show symptoms of the mutation.
Severity of Disease