Affected males develop renal failure as a result of a high protein concentration in the kidneys.
Test specific information
‘Early onset’ – This phrase indicates, that the symptoms of the disease can be detected at a lower age. ‘Early onset’ is the opposite of ‘late onset’, in which symptoms may be present at later ages. The phrases are used because the mutation causing ´early onset´ symptoms may be different compared to the mutations causing ´late onset´ symptoms.
Turn Around Time
The turn-around-time of a test depends to a large extent on the logistics of sample transportation to the laboratory. After receiving the sample at the test location, you can normally expect the result within 10 working days. A longer delivery time applies to tests carried out by a Partner Lab.
Location of disease or trait
This disease is present in the entire body, but causes main effects in the internal organs such as stomach, intestinal tract, liver and / or kidneys. In a number of cases, the disease affects one major internal organ.
This DNA test is available for the following breeds: Samoyed. Additional information is available in the Frequently Asked Questions (FAQ).
For this DNA test we accept the following materials: Semen, Swab, Tissue, Blood EDTA, Blood Heparin. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.
The following results are possible for a female: the mode of inheritance is based on recessive or dominant patterns.
The following results are possible for a male:
- A male animal has the sex chromosome Y and a healthy allel. When used in breeding, this animal will not become affected by the disease, nor will the disease be inherited to the next generation.
- A male animal has the sex chromosome Y and a disease allel. When used in breeding, this animal will become affected by the disease. Also, male offspring will receive the Y-chromosome, whereas female offspring will receive the disease allele.
The disease is inherited in an X-chromosomal manner. This means, that female individuals can be free (homozygous normal), affected (homozygous affected) or carrier (heterozygous).
Male individuals carry only one copy of the X-chromosome, which results in the effect that male carriers will also be affected.
Female carriers may spread the disease in a population without showing symptoms themselves. Because of this, it is extremely important to identify carriers correctly to prevent spreading of a disease.
Severity of Disease