Background

Dilated cardiomyopathy (DCM), the most common form of cardiomyopathy, often leads to heart failure and sudden death.

Test specific information

Different risk factors for DCM have been discussed in the scientific community. Some seem to show a line-specific effect, indicating quite recent new mutational events. However, based on the current scientific literature, the PDK4 mutation is the only significant mutation in Dobermans causing DCM but could lead to confusing results as the mutation might be not significant in the line of the dog of interest.

Age

The genetic factor is continuously present, and will always be visible.

Turnaround time

The Turnaround Time (TAT) depends on various factors, such as the shipment time of your sample to the test location, the test method(s) and whether the tests are performed completely or partially by a Partner Lab or Patent owner.

The TAT of tests performed at our facilities is normally 10 working days after receipt of the sample at the testing laboratory (VHL, VHP or Certagen). For tests performed by a Partner Laboratory (so-called "partner lab test") or patent owner, the TAT is at least 20 working days after receipt of your sample. Because the shipment time to our Partner Labs or patent owner may vary due to factors we cannot influence, the mentioned 20 working days are therefore an estimate.

PLEASE NOTE
Sometimes it is necessary to re-run your sample. We call this a retest. In that case, the TAT will of course be extended.

Location of disease or trait

This disease leads to a loss of heart function.

Breed dependence

This DNA test is available for the following breeds: Doberman Pinscher, Dobermann. Additional information is available in the Frequently Asked Questions (FAQ).

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Tissue, Swab, Semen. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

The disease is of multifactorial origin, which means that the symptoms are combination of genetic factors as well as the environment. This marker is part of a panel of genetic factors influencing this disease.

Inheritance

The disease is of multifactorial origin, which means that the symptoms are a combination of genetic factors as well as the environment.

Severity of Disease

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