Background

Dilated cardiomyopathy (DCM), the most common form of cardiomyopathy, often leads to heart failure and sudden death.

Test specific information

Different risk factors for DCM have been discussed in the scientific community. Some seem to show a line-specific effect, indicating quite recent new mutational events. However, based on the current scientific literature, the PDK4 mutation is the only significant mutation in Dobermans causing DCM but could lead to confusing results as the mutation might be not significant in the line of the dog of interest.

Age

The genetic factor is continuously present, and will always be visible.

Turn Around Time

The turn-around-time of a test depends to a large extent on the logistics of sample transportation to the laboratory. After receiving the sample at the test location, you can normally expect the result within 10 working days. A longer delivery time applies to tests carried out by a Partner Lab.

Location of disease or trait

This disease leads to a loss of heart function.

Breed dependence

This DNA test is available for the following breeds: Doberman Pinscher, Dobermann. Additional information is available in the Frequently Asked Questions (FAQ).

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Tissue, Swab, Semen. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

The disease is of multifactorial origin, which means that the symptoms are combination of genetic factors as well as the environment. This marker is part of a panel of genetic factors influencing this disease.

Inheritance

The disease is of multifactorial origin, which means that the symptoms are a combination of genetic factors as well as the environment.

Severity of Disease

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