Dr. van Haeringen Laboratorium B.V.

H465 Gastric Dilatation-Volvulus_2

Background

Gastric dilatation-volvulus (GDV) especially occurs in large breeds of dogs. Dilatation of the stomach is caused by accumulation of gas, which results from bacterial fermentation and torsion of the stomach on its axis prevents the escape of gas. The expansion of the stomach leads to the compression of vital blood vessels and thus to a life-threatening situation. The causes of GDV are not clearly understood, but genetic factors seem to be important risk factors. Possibly variations in genes of the immune system may predispose dogs to GDV. This hypothesis was followed up in a study and associations between specific alleles of the genes DLA88, DRB1 and TLR5 and GDV were discovered.

Test specific information

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Age

The disease may show itself on different ages, in which it cannot be estimated when the first symptoms may show themselves. Differences may exist between littermates, and between breeds.

Turnaround time

The Turnaround Time (TAT) depends on various factors, such as the shipment time of your sample to the test location, the test method(s) and whether the tests are performed completely or partially by a Partner Lab or Patent owner.

The TAT of tests performed at our facilities is normally 10 working days after receipt of the sample at the testing laboratory (VHL, VHP or Certagen). For tests performed by a Partner Laboratory (so-called "partner lab test") or patent owner, the TAT is at least 20 working days after receipt of your sample. Because the shipment time to our Partner Labs or patent owner may vary due to factors we cannot influence, the mentioned 20 working days are therefore an estimate.

PLEASE NOTE
Sometimes it is necessary to re-run your sample. We call this a retest. In that case, the TAT will of course be extended.

Location of disease or trait

This disease is present in the entire body, but causes main effects in the internal organs such as stomach, intestinal tract, liver and / or kidneys. In a number of cases, the disease affects one major internal organ.

Breed dependence

This DNA test is available for the following breeds: Great Dane. Additional information is available in the Frequently Asked Questions (FAQ).

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Semen, Swab, Tissue. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

The disease is of multifactorial origin, which means that the symptoms are a result of the combination of genetic factors as well as the environment.

For each genetic factor of a multifactorial disease, a favourable allele exists. The results for this allele are inidcated as 'Normal'. Animals carrying one copy of the undesirable genetic variant are indicated as 'Carrier', whereas animals carrying two copies of the undesirable genetic variant are indicated as 'Affected'.

Inheritance

The disease is of multifactorial origin, which means that the symptoms are a combination of genetic factors as well as the environment.

Severity of Disease

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Code H465

Gastric Dilatation-Volvulus_2

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