Dr. van Haeringen Laboratorium B.V.

H466 Gastric Dilatation-Volvulus_3

Background

Gastric dilatation-volvulus (GDV) especially occurs in large breeds of dogs. Dilatation of the stomach is caused by accumulation of gas, which results from bacterial fermentation and torsion of the stomach on its axis prevents the escape of gas. The expansion of the stomach leads to the compression of vital blood vessels and thus to a life-threatening situation. The causes of GDV are not clearly understood, but genetic factors seem to be important risk factors. Possibly variations in genes of the immune system may predispose dogs to GDV. This hypothesis was followed up in a study and associations between specific alleles of the genes DLA88, DRB1 and TLR5 and GDV were discovered.

Test specific information

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Age

The disease may show itself on different ages, in which it cannot be estimated when the first symptoms may show themselves. Differences may exist between littermates, and between breeds.

Turn Around Time

The turn-around-time of a test depends to a large extent on the logistics of sample transportation to the laboratory. After receiving the sample at the test location, you can normally expect the result within 10 working days. A longer delivery time applies to tests carried out by a Partner Lab.

Location of disease or trait

This disease is present in the entire body, but causes main effects in the internal organs such as stomach, intestinal tract, liver and / or kidneys. In a number of cases, the disease affects one major internal organ.

Breed dependence

This DNA test is available for the following breeds: Great Dane. Additional information is available in the Frequently Asked Questions (FAQ).

Sample type

For this DNA test we accept the following materials: Swab, Tissue, Semen, Blood EDTA, Blood Heparin. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

The disease is of multifactorial origin, which means that the symptoms are a result of the combination of genetic factors as well as the environment.

For each genetic factor of a multifactorial disease, a favourable allele exists. The results for this allele are inidcated as 'Normal'. Animals carrying one copy of the undesirable genetic variant are indicated as 'Carrier', whereas animals carrying two copies of the undesirable genetic variant are indicated as 'Affected'.

Inheritance

The disease is of multifactorial origin, which means that the symptoms are a combination of genetic factors as well as the environment.

Severity of Disease

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Code H466

Gastric Dilatation-Volvulus_3

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