Dr. van Haeringen Laboratorium B.V.

H677 Von-Willebrands Disease Type 1

Background

Von Willebrand disease (vWD) is the most common inherited bleeding disorder, which is highly heterogeneous ranging from an asymptomatic laboratory abnormality to a life threatening bleeding. The condition is caused by a quantitative or qualitative deficiency of von Willebrand factor (vWF). It has been classified into six subgroups based on evaluation of the vWF level and function. The disease is characterized by the abnormally low production of von Willebrands factor which plays a key role in the complex process of clotting a damaged blood vessel. Because it is very uncommon for carriers to show symptoms of vWD this condition is considered to be recessive.

Test specific information

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Age

The genetic factor is continuously present, and will always be visible.

Turnaround time

The Turnaround Time (TAT) depends on various factors, such as the shipment time of your sample to the test location, the test method(s) and whether the tests are performed completely or partially by a Partner Lab or Patent owner.

The TAT of tests performed at our facilities is normally 10 working days after receipt of the sample at the testing laboratory (VHL, VHP or Certagen). For tests performed by a Partner Laboratory (so-called "partner lab test") or patent owner, the TAT is at least 20 working days after receipt of your sample. Because the shipment time to our Partner Labs or patent owner may vary due to factors we cannot influence, the mentioned 20 working days are therefore an estimate.

PLEASE NOTE
Sometimes it is necessary to re-run your sample. We call this a retest. In that case, the TAT will of course be extended.

Location of disease or trait

This disease results in a reduced clotting of blood. As a result, affected individuals will show increased bloodflow during injuries.

Breed dependence

This DNA test is available for the following breeds: Australian Shepherd, Australian Silky Terriër, Bernese Mountain Dog, Cairn Terrier, Coton de Tulear, Doberman Pinscher, Dobermann, Drentsche Patrijshond, German Pinscher, Giant Spitz, Great Dane, Hungarian Puli, Kerru Blue Terrier, Manchester Terrier, Medium Spitz, Miniature Spitz, Papillion, Pembroke Welsh Corgi, Phalene, Pomeranian, Poodle, Pug Dog, Schipperke, Stabijhoun, Volpino Italiano, Wolfspitz. Additional information is available in the Frequently Asked Questions (FAQ).

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Semen, Swab, Tissue. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.

An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding 50 percent of the offspring will receive the disease allele. Carriers will also become ill.

An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected will also become ill.

Inheritance

This genetic factor is inherited in an autosomal, dominant, mode. This means, that the individual can be free of the mutation (homozygote normal), affected (homozygous affected) or carrier (heterozygous affected). Both carriers and affected individuals will show symptoms of the mutation.

Severity of Disease

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Code H677

Von-Willebrands Disease Type 1

€ 47,80 (Incl. 21% VAT)
€ 39,50 (Excl. VAT)
Quantity