Dr. van Haeringen Laboratorium B.V.

H696 Warburg Micro Syndrome 1 (WARBM1)

Background

Warburg micro syndrome (WARBM) in human is a genetic heterogeneous disease characterized by microcephaly, intellectual disability, brain, ocular, and endocrine anomalies. In Huskies, microphtalmia and progressive neurological disorders (i.e. ataxia) have been observed.

Test specific information

In Human, the Warburg micro syndrome (WARBM) is a genetic heterogeneous disease characterized by microcephaly, intellectual disability, brain-, ocular-, and endocrine anomalies. The group of Prof. Leeb from the University of Bern identified a mutation in Huskies, specifically in those bred for sledging, which apparently causes the same symptoms: microphtalmia and progressive neurological disorders (i.e. ataxia). Because of the clinical symptoms, diseased dogs are euthanized within a few months. In cooperation with Prof. Leeb, we have developed a routine test, helping to avoid the birth of dogs with this fatal disease.

Age

Symptoms will develop at a young age. Within a few hours to a maximum of several weeks after birth, the characteristics that go with these genetic effects will become visible.

Turn Around Time

The turn-around-time of a test depends to a large extent on the logistics of sample transportation to the laboratory. After receiving the sample at the test location, you can normally expect the result within 10 working days. A longer delivery time applies to tests carried out by a Partner Lab.

Location of disease or trait

This disease leads to a loss of brain function.

Breed dependence

This DNA test is available for the following breeds: Siberian Huski. Additional information is available in the Frequently Asked Questions (FAQ).

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Semen, Swab, Tissue. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.

An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding 50 percent of the offspring will receive the disease allele. Carriers will not become ill.

An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected will become ill.

Inheritance

This genetic factor is inherited in an autosomal, recessive, mode. This means, that the individual can be free of the disease (homozygote normal), affected (homozygous affected) or carrier (heterozygous).

Carriers may spread the mutation in a population without showing symptoms themselves. Because of this, it is extremely important to identify carriers correctly to prevent spreading of a mutation.

Severity of Disease

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Code H696

Warburg Micro Syndrome 1 (WARBM1)

€ 47,80 (Incl. 21% VAT)
€ 39,50 (Excl. VAT)
Quantity