Dr. van Haeringen Laboratorium B.V.

H932 Ventricular Arrhythmias and Sudden Death

Background

Ventricular arrhythmias are abnormal heartbeats that originate in the lower heart chambers and causes the heart to beat too fast, too slow or irregularly. A single missense variant in the QIL1 gene was associated with the cardiac arrhythmia. The missense variant in the QIL1 gene causes mitochondrial cardiomyopathy characterised by cristae abnormalities and cardiac arrhythmias in a canine model.

Clinical signs include chest pain, very fast heartbeat (tachycardia), dizziness, nausea, shortness of breath, seizures, collapse or near collapse (stumbing, being wobbly). In addition, the disease can lead to sudden death.

Test specific information

This test is based on an association study. This study described a genetic mutation that is associated with an inherited ventricular arrhythmia in Rhodesian Ridgebacks. The inheritance of this mutation is not yet known. Autosomal recessive pattern is proposed, although autosomal dominant with incomplete penetrance cannot be ruled out.

Age

The genetic factor is continuously present, and will always be visible.

Turnaround time

The Turnaround Time (TAT) depends on various factors, such as the shipment time of your sample to the test location, the test method(s) and whether the tests are performed completely or partially by a Partner Lab or Patent owner.

The TAT of tests performed at our facilities is normally 10 working days after receipt of the sample at the testing laboratory (VHL, VHP or Certagen). For tests performed by a Partner Laboratory (so-called "partner lab test") or patent owner, the TAT is at least 20 working days after receipt of your sample. Because the shipment time to our Partner Labs or patent owner may vary due to factors we cannot influence, the mentioned 20 working days are therefore an estimate.

PLEASE NOTE
Sometimes it is necessary to re-run your sample. We call this a retest. In that case, the TAT will of course be extended.

Location of disease or trait

This disease leads to a loss of heart function.

Breed dependence

This DNA test is available for the following breeds: Rhodesian Ridgeback. Additional information is available in the Frequently Asked Questions (FAQ).

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Semen, Tissue, Swab. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

Inheritance

The inheritance of this disease is not completely clear.

Severity of Disease

-

Code H932

Ventricular Arrhythmias and Sudden Death

€ 57,48 (Incl. 21% VAT)
€ 47,50 (Excl. VAT)
Quantity