Dr. van Haeringen Laboratorium B.V.

P705 Hyperkalemic Periodic Paralysis (HYPP)

Background

HYPP was recognized and described in the 1980s. The development of a diagnostic test illustrates the power of knowledge in other species (including humans). For this particular disease, which has identical characteristics between humans and horses, human research directly led to the identification of a mutation in horses with HYPP. Horses affected by HYPP have severe muscle problems following exercise. Even horses which are heterozygous may show symptoms of the disease.

Test specific information

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Age

The genetic factor is continuously present, and will always be visible.

Turn Around Time

The turn-around-time of a test depends to a large extent on the logistics of sample transportation to the laboratory. After receiving the sample at the test location, you can normally expect the result within 10 working days. A longer delivery time applies to tests carried out by a Partner Lab.

Location of disease or trait

The disease is present in muscle. Depending on the effect, degeneration of muscle may take place. Alternatively, recovery following exercise may be deteriorated.

Breed dependence

This DNA test is available for the following breeds: Quarter Horse. Additional information is available in the Frequently Asked Questions (FAQ).

Sample type

For this DNA test we accept the following materials: Hair, Semen, Blood EDTA, Blood Heparin, Tissue. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.

An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding 50 percent of the offspring will receive the disease allele. Carriers will also become ill.

An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected will also become ill.

Inheritance

This genetic factor is inherited in an autosomal, dominant, mode. This means, that the individual can be free of the mutation (homozygote normal), affected (homozygous affected) or carrier (heterozygous affected). Both carriers and affected individuals will show symptoms of the mutation.

Severity of Disease

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Code P705

Hyperkalemic Periodic Paralysis (HYPP)

€ 47,80 (Incl. 21% VAT)
€ 39,50 (Excl. VAT)
Quantity