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Copper Toxicosis is a complex genetic disease in the Labrador Retriever, Golden Retriever and other breeds.
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Algemene informatie
Copper Toxicosis is a complex genetic disease in the Labrador Retriever, Golden Retriever and other breeds. Affected dogs retain too much copper from their diet, causing liver damage and associated negative effects. Several different mutations can contribute to this disorder, including a mutation to the ATP7B gene (referred to as Wilson Disease). Literature indicates that the dominant mutation to RETN analyzed in this test reduces hepatic copper levels, potentially protecting against copper toxicosis. The condition Menkes Disease has been documented to have a similar effect. Copper toxicosis can also be mitigated with a low-copper, high-zinc specialized diet.
Klinische eigenschappen
It has been described that this variant reduces copper levels and therefor is pottentially protecting againt copper toxicosis. The symptoms of copper toxicosis can include vomiting, decreased apetite and weight loss, excessive thirst, frequent urination, (bloody) diarrhea, jaundice, ascites (a swollen, fluid-filled abdomen), and hepatic encephalopathy (disorientation, aggression, seizures and ultimately coma).
Extra informatie
Further studying of this variant is necessary to assess RETN expression levels in liver tissue and the function of it. The mode of inheritance has not yet been described in literarture.
Referenties
Pubmed ID: 33142854
Omia ID: